FDA approves first SMA muscle-loss drug; studies link gut, genes to brain aging

· 8 source(s)

Short summary

STAT reports that Scholar Rock won FDA approval for Isembyld, the first drug targeting SMA muscle loss; a late-stage trial found motor skills improved after a year when combined with an SMN2-targeting drug. A study in Pediatrics, reported by Medical Xpress, found burnout indicators among pediatricians decreased from 2021 to 2025. STAT also reports an E.U. advocate general recommended annulling part of a directive requiring drugmakers to finance 80% of wastewater treatment costs. Medical Xpress items describe UCLA findings linking brain aging speed to gut bacteria, Columbia University research

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  • Drug approvals and policy
    • STAT: FDA approves Isembyld for SMA muscle loss
    • STAT: trial shows motor skill gains with SMN2 drug
    • STAT: E.U. adviser urges annulling wastewater cost rule
  • Brain aging and Alzheimer's
    • UCLA links brain aging speed to gut bacteria
    • Columbia predicts Alzheimer's symptoms three to six years ahead
    • Blood and gene tests used for prediction
  • Genetics and disease risk
    • Complex traits draw heritability from intergenic DNA
    • Schizophrenia and cholesterol cited as examples
    • Huntsman: obesity blocks process killing cancer cells
  • Clinical practice and workforce
    • Pediatrics study: pediatrician burnout indicators fell 2021-2025
    • AI tools could individualize postoperative opioid prescribing

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Sources

Written by an AI model from the sources listed above, then published without edits. It summarises what those sources reported and adds nothing of its own — for the full story, follow the links. Model: deepseek-chat.

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